In the first study from the Clinical and Translational Report, yeast deprived of food periodically were shown to have longer life expectancy than yeast fed normally. The second study involved feeding a group of mice a specialized diet for four days a month. The diet reduced both caloric intake and protein intake. The scientists tested markers in the blood of the mice and found that the diet emulated prolonged water-only fasting. After returning to regular feeding, the mice regained most, but not all of the lost weight. Differences between the Fasting Mimicking Diet group and the control group include improved metabolism and cognitive function, gradual weight loss, muscle rejuvenation, higher bone density, 40% fewer malignant lymphomas, immune system regeneration, and longer average, though not absolute, life expectancy.
A third study was done using people. There were nineteen FMD participants and nineteen control participants with a broad range of ages represented (19-75). There were members of both sexes and most races, so that the study represented a general cross section of adult population. The individuals in the Fasting Mimicking Diet group were provided with the food they were required to eat during five FMD days for each of three months. Scientists were pleased with the level of compliance with the diet, and most reported only mild or no negative effects on the fasting days. Results showed that the FMD participants experienced an average 3% reduction in weight, a reduction in visceral fat, a reduction in C-reactive protein, and rejuvenation for the immune system.